Email this article 
Open Access
Subscription or Fee Access
Identification of Charged and Neutral Fragments Produced by CID - COINTOF Technique via Analysis of Their Signal Amplitude Distributions at the MCP Detector
(*) Corresponding author
DOI's assignment:
the author of the article can submit here a request for assignment of a DOI number to this resource!
Cost of the service: euros 10,00 (for a DOI)
Abstract
Detection and characterization of fragments produced by CID-COINTOF (Collision Induced Dissociation- COrrelated Ion and Neutral Time Of Flight) technique of precursor ions is considered as a rigorous challenge in tandem mass spectrometry. Here we show a new method allowing to access to information on the charged and neutral fragments, produced through a specific dissociation channel of a precursor ions, via the analyses of the amplitude distributions of their output signals at the same MCP detector. The effect of charge, size, mass and velocity of fragments on their signal amplitude distributions are highlighted. By analyzing and comparing the different amplitude distributions, the detected fragments can be identified. In the present work, the water molecules H2O and the correlated ion H+(H2O) produced by CID of protonated water trimer precursor ion H+(H2O)3 are identified via the analysis of their output signal amplitude distributions. Most importantly, the production and the identification of neutral water dimer ( H2O)2 is confirmed by this new method.
Copyright © 2019 Praise Worthy Prize - All rights reserved.
Keywords
References
Z. P. Wang et al, Microscopic Studies of Atom - Water Collisions, Int. J. Mass Spectrom. 285 (2009), 143 - 148.
F. Dong et al, Dynamics and fragmentation of van der Waals clusters: (H2O)n, (CH3OH)n, and (NH3)n upon ionization by a 26.5eV soft x-ray laser, J. Chem. Phys. 124 (2006), 224319 - 224336.
https://doi.org/10.1063/1.2202314
A. Fujii et al, Infrared Spectroscopic Studies on hydrogen-bonded water networks in the gas phase clusters, Int. Rev. Phys. Chem. 32 (2013), 266 - 307.
https://doi.org/10.1080/0144235x.2012.760836
S. Tomita et al, High energy collisions of protonated water clusters, Euro. Phys. J. D 16 (2001), 119 - 122.
B.T. Chait, Mass Spectrometry: Bottom-Up or Top-Down? Science 314 (2006), 65 - 66.
https://doi.org/10.1126/science.1133987
M.-Q. Zuo et al, Characterization of collision-induced dissociation of deprotonated peptides of 4 - 16 amino acids using high-resolution mass spectrometry, Int. J. Mass Spectrom. 445 (2019), 116186 - 116193.
https://doi.org/10.1016/j.ijms.2019.116186
Y. Liang et al, Collision-Induced Dissociation of Deprotonated Peptides. Relative Abundance of Side-Chain Neutral Losses, Residue-Specific Product Ions, and Comparison with Protonated Peptides, J. Am. Soc. Mass Spectrom., 29 (2017), 463 - 469.
https://doi.org/10.1007/s13361-017-1842-5
J. Ren et al, Fragmentation Patterns and Mechanisms of Singly and Doubly Protonated Peptoids Studied by Collision Induced Dissociation, J. Am. Soc. Mass Spectrom., 27 (2016), 646 - 661.
https://doi.org/10.1007/s13361-016-1341-0
D. Nikolić et al, Collision-induced dissociation of phenethylamides: role of ion-neutral complexes, Mass Spectrometry, 31 (2017), 1385–1395.
https://doi.org/10.1002/rcm.7915
SH Giese et al, A Study into the Collision-induced Dissociation (CID) Behavior of Cross-Linked Peptides, Mol Cell Proteomics., 15 (2016), 1094 - 104.
https://doi.org/10.1074/mcp.m115.049296
F. Gobet et al, Event-by-Event Analysis of Collision-Induced Cluster-Ion Fragmentation: Sequential Monomer Evaporation versus Fission Reactions, Phys. Rev. Lett. 86 (2001), 4263 - 4266.
https://doi.org/10.1103/physrevlett.86.4263
M. Farizon, et all, Method for tandem time of flight analysis and analysis appliance using said method, Université Claude Bernard Lyon 1, Dépôt de brevet n° 09 58991 du 15 Décembre 2009, PCT/FR2010/052733 patent; Jul, 7 2011: WO 2011/080455
Abou-Saleh, K., Harb, M., Dissociation Process of Protonated Water Dimer and Trimer Clusters via COINTOF Mass Spectrometry: Identification of Neutral Water Dimer, (2019) International Review of Physics (IREPHY), 13 (1), pp. 1-7.
ROOT © : A Data Analysis Framework, http://root.cern.ch/drupal/
C. Teyssier et al, A novel “correlated ion and neutral time of flight” method: Event-by-event detection of neutral and charged fragments in collision induced dissociation of mass selected ions, Rev. Sci. Instrum. 85 (2014), 015118 - 015124.
https://doi.org/10.1063/1.4863015
G. Bruny et al, A new Experimental Setup Designed for the Investigation of Irradiation of Nanosystems in the Gas Phase: A High Intensity Mass-and-Energy selected Cluster Beam, Rev. Sci. Instrum. 83 (2012), 013305 - 013307.
https://doi.org/10.1063/1.3677845
W.C. Wiley et al, Time‐of‐Flight Mass Spectrometer with Improved Resolution, Rev. Sci. Instrum. 26 (1955), 1150 - 1157.
I.G. Gurtubay et al, Dissociation energy of the water dimer from quantum Monte Carlo calculations, J. Chem. Phys. 127 (2007), 124306 - 124314.
https://doi.org/10.1063/1.2770711
J. Laskin et al, Kinetic energy release distributions in mass spectrometry, J. Mass Spectrom. 36 (2001), 459 - 478.
https://doi.org/10.1002/jms.164
SIMION 3D 7.0 © : D.A. Dahl, Scientific Instrument Services Inc., Boise Idaho (2000).
J.C. Jiang et al, Infrared Spectra of H+(H2O)5-8 Clusters: Evidence for Symmetric Proton Hydration, J. Am. Chem. Soc. 122 (2000), 1398 - 1410.
H.C. Chang et al, Recent advances in understanding the structures of medium-sized protonated water clusters, Int. Rev. Phys. Chem. 24 (2005), 553 - 578.
Refbacks
Please send any question about this web site to info@praiseworthyprize.com
Copyright © 2005-2024 Praise Worthy Prize
