Identification of Charged and Neutral Fragments Produced by CID - COINTOF Technique via Analysis of Their Signal Amplitude Distributions at the MCP Detector
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Detection and characterization of fragments produced by CID-COINTOF (Collision Induced Dissociation- COrrelated Ion and Neutral Time Of Flight) technique of precursor ions is considered as a rigorous challenge in tandem mass spectrometry. Here we show a new method allowing to access to information on the charged and neutral fragments, produced through a specific dissociation channel of a precursor ions, via the analyses of the amplitude distributions of their output signals at the same MCP detector. The effect of charge, size, mass and velocity of fragments on their signal amplitude distributions are highlighted. By analyzing and comparing the different amplitude distributions, the detected fragments can be identified. In the present work, the water molecules H2O and the correlated ion H+(H2O) produced by CID of protonated water trimer precursor ion H+(H2O)3 are identified via the analysis of their output signal amplitude distributions. Most importantly, the production and the identification of neutral water dimer ( H2O)2 is confirmed by this new method.
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