Potential Drug Delivery Applications of Chitosan Based Nanomaterials
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Abstract
Polymeric nanoparticles have long been sought after as carriers for systemic and targeted drug delivery. Chitosan is biopolymers having immense structural possibilities for chemical and mechanical modifications to generate novel properties, functions and applications especially in biomedical area. Chitosan is effective material for biomedical applications because of their biocompatibility, biodegradability and non-toxicity, apart from their antimicrobial activity and low immunogenicity, which clearly points to an immense potential for future development. These candidate biopolymers can be easily processed into gels, sponges, membranes, beads and scaffolds forms. This review emphasizes recent research on different aspects of chitosan based nanomaterials, including the preparation and applications of chitosan based nano material and macro particle. This review also includes the factors that affect the entrapment efficiency and release kinetics of drugs from chitosan microspheres
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