Antioxidant, Lipo-Protective and Antibacterial Activities of Phytoconstituents Present in Solanum Xanthocarpum Root

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Present study reports the biochemical and antibacterial activities of phytoconstituents present in roots of non toxic weed S. xanthocarpum. Total phenolic contents were quantified in different fractions. Ethanolic (ET) fraction was richest (194.44±0.41 mgPGE/g) followed by ethyl acetate (EA) and aqueous (AQ) fractions (115±0.25 and 88.75± mgPGE/g, respectively). Antioxidant activity was evaluated using reducing power assay (RPA) while lipo-protective activity was determined by lipid peroxidation inhibition (LPOI)/TBARS assays in rat kidney tissue. ET, AQ and HX (hexane) fractions demonstrated significant reducing power at 1000 µg/ml concentration showing dose dependent response in the range 200-1000 µg/ml. ET and AQ fractions exhibited 52% and 45% LPOI, respectively in TBARS assay. Positive correlation was observed between total phenol and RPA (r2=0.399) as well as %LPOI (r2=0.540). Similarly relationship between RPA and %LPOI was also found to be positive (r2=0.379). Pathogenic bacteria Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumonia and Staphylococcus aureus exhibited resistance against AQ fraction in disc diffusion assay
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Antioxidant; Extracts; Free Radicals; LPOI; Phenols; Reducing Power; S. Xanthocarpum

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A. Mishra, S. Kumar, A. Bhargava, B. Sharma, A.K. Pandey, Studies on in vitro antioxidant and antistaphylococcal activites of some important medicinal plants, Cellular and Molecular Biology, Volume 57 (1), 2011, pages 16-25.

B. Halliwell, Free Radicals, antioxidants and human disease: curiosity, cause or consequence?, Lancet, Volume 344, 1994, Pages 721-724.

L. Rackova, M. Oblozinsky, D. Kostalova, V. Kettmann, L. Bezakova, Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids, Journal of Inflammation, Volume 4:15, 2007.

S. Chanda, R. Dave, In Vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview , African Journal of Microbiology, Volume 3(Issue 13), 2009, Pages 981-996.

D.S. Arora, P. Chandra, Antioxidant Activity of Aspergillus fumigates, ISRN Pharmacology,Volume 2011, 2011, DOI: 10.5402/2011/619395.

C. Rice-Evans, Flavonoids andiIsoflavones: Absorption, Metabolism and Bioactivity, Free Radical Biology and Medicine, Volume 36, 2004, Pages 827-828.

G.H. Shahidi Bonjar, M.H. Fooladi, M.J. Mahadevi, A. Shahghasi, Broadspectrim, a novel antibacterial from Streptomyces spp., Biotechnology, Volume 3, 2004, Pages 126-130.

J. Davis, Inactivation of antibiotics and the dissemination of resistance genes, Science, Volume 264, 1994, Pages 375-382.

R.F. Service, Antibiotics that resist resistance, Science, Volume 270, 1995, Pages 724- 727.

P. Shears, Antimicrobial resistance in the tropics, Tropical Doctor, Volume 30, Issue 2, 2000, Pages 114-116.

Anonymous, The wealth of India-Raw materials vol. IX: Rh–So. (CSIR, New Delhi, 1989, pp. 393–394).

S. Govindan, S. Viswanathan, V. Vijayasekaran, R. Alagappan, Further Studies on the clinical efficacy of Solanum trilobatum in bronchial asthma, Phytotherapy Research, Volume 18, 2004, Pages 805-809.

G. Gunaselvi, V. Kulasekaren, V. Gopal, Anthelmintic activity of the extracts of Solanum xanthocarpum Schrad and Wendl fruits (Solanaceae). International Journal of PharmTech Research, Volume 2, Issue 3, 2010, pages 1772-1774.

C. Roshy Joseph, R. Ilanchezhian, B.J. Patgiri, Therapeutic potentials of kantakari (Solanum Xanthocarpum Schrad. & Wendl.). Ayurpharm International Journal of Ayurveda and Allied Sciences, 2012, Volume 2, Pages 46 – 53.

K.R. Kirtikar, B.D. Basu, Indian Medicinal Plants, vol. I., 2nd ed. (International Book Distributors, Dehradun, India, 2008).

A.K. Najmi, K.K. Pillai, S.N. Pal, M. Aqil, Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats, Journal of Ethnopharmacology, Volume 97, 2005, pages 521–525.

A.K. Mishra, A. Mishra, H.K. Kehri, B. Sharma, A.K. Pandey, Inhibitory activity of Indian spice plant Cinnamomum zeylanicum extracts against Alternaria solani and Curvuluria lunata, the pathogenic dematiaceous moulds, Annals of Clinical Microbiology and Antimicrobials, Volume 8:9, 2009.

A.K. Pandey, Anti-staphylococcal activity of a pan-tropical aggressive and obnoxious weed Parthenium histerophorus: An in vitro study National Academy Science Letters, Volume 30, 2007, Pages 383-386.

S. Sadasivam, A. Manickam, Biochemical Methods, 2nd edition, (New Age International (P) Ltd, New Delhi, 1996, pp. 193-94).

R.P. Singh, K.N. Chidambara Murthy, G.K. Jayaprakash, Studies on the antioxidant activity of Pomegranate (Punica granatum) peel and seed extracts using In Vitro models, Journal of Agricultural and Food Chemistry, Volume 50, 2002, Pages 81-86.

M. Oyaizu, Studies on products of browning reactions: antioxidative activities of products of browning reaction prepared from glucosamine, Japanese Journal of Nutrition, Volume 44, 1986, Pages 307-315.

G.K. Jayaprakasha, R.P. Singh, K.K. Sakariah, Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro, Food Chemistry, Volume 73, 2001, Pages 285-290.

A.K. Pandey, A.K. Mishra, A. Mishra, S. Kumar, A. Chandra, Therapeutic potential of C. zeylanicum extracts: an antifungal and antioxidant perspective, International Journal of Biological and Medical Research, Volume 1, Issue 4, 2010, pages 228-233.

B. Halliwell, J.M.C. Gutteridge, Protection against lipid peroxidation, In: Free radicals in biology and medicine, 2nd edn., (Japan Scientific Societies Press, Tokyo,1989)

A.K. Mishra, A. Mishra, A. Bhargava and A. K. Pandey, Antimicrobial activity of essential oils from the leaves of Cinnamomum spp. Natlional Academy Science Letters, Volume 31, 2008, Pages 341-345.

F.N. Ko, Z. J. Cheng, C. N. Lin and C. M. Teng, Scavenger and antioxidant properties of prenylflavones isolated from Artocarpus heterophyllus, Free Radical Biology and Medicine, Volume 25, 1998, Pages 160-168.

S. Mathew, T.E. Abraham, In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies, Food and Chemical Toxicology, Volume 44, 2006, Pages 198-206.

C. Rice-Evans, N. Miller, G. Paganga, Antioxidant properties of phenolic compounds, Trends in Plant Science, volume 2, 1997, Pages 152-159.

S.M. Nabavi, M.A. Ebrahimzadeh, S.F. Nabavi, M. Fazelian, B. Eslami, In vitro antioxidant and free radical scavenging activity of Diospyros lotus and Pyrusboissieriana growing in Iran. Pharmacognosy Magazine, Volume 4, Issue 18, 2009, Pages 123-127.

M.A. Jayasri, L. Mathew, et al, A report on the antioxidant activity of leaves & rhizome of Costus pietus D.Don, International Journal of Integrative Biology, volume 5, Issue 1, 2009, Pages 20-26.

S. Shyamala gowri, K. Vasantha, Free radical scavenging and antioxidant activity of leaves from agathi (Sesbania grandiflora) (L.) Pers, American-Eurasian Journal of Scientific Research., volume 5, 2010, Pages 114-119.

J.A. Badmus, T.O. Adedosu, J.O. Fatoki, V.A. Adegbite, O.A. Adaramoye, O.A. Odunola, Lipid peroxidation inhibition and antiradical activities of some leaf fractions of Mangifera indica, Acta Poloniae Pharmaceutica, Volume 68, Issue 1 , 2011, Pages 23-9.

K.H. Cheeseman, T.F. Slater, An introduction to free radical biochemistry, British Medical Bulletin, Volume 49, 1993, Pages 481–493.

D.R. Janero, Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury, Free Radical Biology and Medicine, Volume 9, 1990, Pages 515–540.

C.C. Yen, P.D. Duh, The relationship between antioxidant activity and maturity of peanut hulls, Journal of Agricultural and Food Chemistry, Volume 41, 1993, Pages 67–70.


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