Disease –Age- Correlated Oxidative Status of Patients with Hypertensive and Diabetic Co-Morbidity in Central Hospital, Benin City, Nigeria
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The study was designed to compare oxidative status of sufferers of a co-morbidity of hypertension and diabetes mellitus who have clinical evidence of sustained well controlled blood sugar and blood pressure with that of apparently healthy controls and to see if the variation of this oxidative status with progression (age) of the co-morbidity differ from the observations in previous studies with sufferers of solitary hypertension or diabetes. Blood samples were collected from co-morbidity sufferers (n = 42; 17 males and 25 females ) and 42 apparently healthy volunteers for the determination of plasma levels of two endogenous antioxidant enzymes (superoxide dismutase, SOD, and catalase, CAT) as well as markers of oxidative damage (malondialdehyde, MDA, and erythrocyte osmotic fragility, EOF). Results obtained showed that the blood levels of both SOD and CAT decreased significantly (P<0.001) as age of co-morbidity increases. Also levels of blood MDA and EOF increased with age of co-morbidity (P<0.001). The variation of these indices with disease age was more statistically significant than that observed in earlier studies with solitary diabetes or hypertension. This study shows that oxidative damage is worse in sufferers of hypertensive and diabetic co-morbidity than in sufferers of solitary diabetes or hypertension
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M. Atalay, D. E. Laaksonen, Diabetes, oxidative stress and physical exercise, Jornal of Sport Science andMedicine, 2002,Volume 1, pp.1-14.
P. S. Van-Dam, C. K. Vas, B. S. Asbe, D. W. Erkelens, J. J. M. Marx, W. H. Gispen, B. Bravenboer, The role of oxidative stress in neuropathy and other diabetic complications, Diabetes/Metabolism Review, 1995, Volume 11, pp. 181-192.
D. Giugliano, A. Ceriello, G. Paolisso, Oxidative stress and diabetic vascular complications, Diabetes Care, 1996, Volume 19, pp. 357-267.
M. C. Houston, Nutriceutical, vitamins, oxidants, antioxidants, and minerals in the treatment of hypertension, Prog. Cardiovasc. Dis., 2005, Volume 47(Issue 6), pp. 396-449.
P. Zimmet, P. Lefebvre, The global NIDDM epidemic. Treating the disease and ignoring the symptoms (editorial), Diabetologia, 1996, Volume 39, pp. 1247-1248.
D. E. Laaksonen, M. Atalay, L. Niskanem, J. Mustonen, C. K. Sen, T. A. Lakka, M. I. Uusitupa, Aerobic exercise and lipid profile in type 1 diabetic men: a randomized control trial, Medicine and Science in Sports and Exercise, 2000, Volume 32, pp. 1541- 1548.
S. A. Santini, G. Marra, B. Giadina, P. Cotroneo, A. Mordente, G. E. Martorana, A. Manto, G. Ghirlanda, Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM, Diabetes, 1997, Volume 46, pp. 1853-1858.
D. E. Laaksonen, C. K. Sen, Exercise and oxidative stress in Diabetes Mellitus. in: Handbook of oxidants and antioxidants in Exercise (Ed: Sen. C. K., Parker, C. and Hannien, O. Elsevier, Amsterdam, 2000, pp. 1105-1136)
A. Ceriello, E. Motz, Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes and cardiovascular disease? The common soil hypothesis revisited, Atheriosc. Thromb. Vasc. Biol., Volume 24, pp. 816-823.
S. C. Jones, H. J. Saunders, Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells, Diabetologia, 1998, Volume 42 (Issue 9), pp. 1113-1119.
S. Schiekofer, M. Andrassy, J. Chen, Increased accumulation of the glycoxidation products N(E) carboxylmethyl lysine in human tissues in diabetes and ageing, Diabetes, 2003, Volume 52, pp. 631-633.
L. Quagliaro, L. Piconi, R. Assalone, Intermittent high glucose enhances apoptosis related to oxidative stress in human unblical vein endothelial cells: the role of protein kinase C and NAD(P)H- oxidase activation, Diabetes, 2003, Volume 52 (Issue 11), pp. 2795-804.
I. B. Hirsh, Blood glucose monitoring technology: translating data into practice, American Journal of Medicine, 2005, Volume 118 (Supplementary 5A), pp. 215-265.
C. Kitiyakara, C. S. Wilcox, Antioxidants for hypertension, Nephrology and Hypertension, 1998, Volume 7, pp. 531-538.
M. R. Touyz, Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension, Hypertension, 2004, Volume 44, pp. 248-252.
G. Zalbra, G. San Jose, M. U. Moreno, A. Fortuno, J. Diez, NADPH oxidase-mediated oxidative stress: genetic studies of the p22 (phox) gene in hypertension, Antioxidant Redox Signal, 2005, Volume 7, pp. 1327-1336.
S. Kimura, G. X. Zhang, A. Nishiyama, T. Shokoji, L. Tao, Y. Y. Fan, M. Rahman, Y. Abe, Mitochondria - derived reactive oxygen species and vascular MAD kinases comparison of Angiostensin II nitric oxide, Hypertension, 2005, Volume 45, pp. 438-444.
J. D. Widder, T. J. Guizik, C. F. Mueller, R. E. Clempus, H. H. Schmidt, S. L. Dikalor, K. K. Griendling, D. P. Jones, D. G. Harrison, Role of the multidrug resistant protein - I in hypertension and vascular dysfunction caused by Angiostensin II, Arteriosc. Thromb. Vacs. Biol., 2007, Volume 27, pp. 762-768.
M. Kampa, A. Nistikaki, V. Tsousis, N. Maliaraki, G. Notas, E. Castanas, A new automated method for the determination of the total antioxidant capacity (TAC) of human plasma based on the crocin bleaching array, BMC Clinical Pathology, 2002, Volume 2: Page 3.
J. O. Oyewale, A. A. Sanni, H. A. Ajibade, Effects of temperature, pH, and blood storage on osmotic fragility of duck erythrocytes, Zentralblatt fur veternamedizin., 1991, Volume 38 (Issue 4), 261 – 264.
S. Tsakiris, A. Giannoulia - Karantana, I. H. Simintzi, K. H. Schulpis, The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity, Pharmacology Research, 2005, Volume 53, pp. 1 - 5.
R. Varshney, R. K. Kale, Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes, International Journal of Radiation Biology, 1990, Volume 58, pp. 733-743.
A. Kraus, H. P. Roth, M. J. Kirchgessner, Supplementation with Vitamin C, Vitamin E, or β – Carotene influences osmotic fragility and oxidative damage of erythrocytes of Zinc – deficient rats, Nutrition, 1997, Volume 127, pp. 1290 - 1296.
B. M. Mafuvadze, H. Nyanungo, B. Saina, T. Gorgena, T. Mashamombe, K. H. Eriwanger, Deprivation of drinking water up to 48 hours does not affect the osmotic fragility of erythrocytes from captive helmeted guinea fowl (Numida Mealagris), International Journal of Poultry Science, 2008, Volume 7, pp. 59 - 63.
I. Karabulut, A. Dicle Balkanci, B. Pehlivanoglu, A. Erdem, E. Fadillioglu, Effect of toluene on erythrocyte membrane stability under invivo and invitro conditions and assessment of oxidant/antioxidant status, Toxicology and Industrial Health, 2009, Volume 25, pp. 545 - 550.
I. Fridovich, Superoxide dismutase. An adaptation to a pragmatic gase, Journal of Biology Chemistry, 1989, Volume 264, pp. 7762-7764.
L. Goth, A simple method for the determination of serum catalase activity and revision of reference range, Clinical Chemistry Acta, 1991, Volume 196, pp. 143 - 152.
A. G. Gornall, C. J. Baradawill, D. Maxima, Determination of serum proteins by means of the Biuret reaction, Biology Chemistry, 1949, Volume 177, pp. 751-766.
E. A. Ogbeibu, Biostatistics: A practical approach to research and data handling (Mindex publishing Co. Ltd.), Benin City, Nigeria, 2005, pp. 171 – 173.
O.A. Iyamu, E. C. Onyeneke, O. M. Oluba, J. C. Anionye, O. M. Oyakhire, O. Aigbe, , Disease – age – correlated oxidative status of some patients with solitory diabetes in Central Hospital, Benin City, Nigeria, Journal Research in Biology, 2011, Volume 2, pp. 1-7.
O.A. Iyamu, E. C. Onyeneke, O. M. Oluba, J. C. Anionye, O. M. Oyakhire, O. Aigbe, Disease – age – correlated oxidative status of some patients with solitory diabetes in Central Hospital, Benin City, Nigeria.Advance Laboratory Medicine International, 2011, Volume 1 (Issue 5) (Accepted for publication).
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