PNA Oligomers as Tools for Targeting G-Quadruplex Structures
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G-quadruplex-forming sequences (QFS) are widely distributed in the human genome, including chromosomal telomeres and regulatory regions of oncogenes, and are involved in a variety of biological contexts. Molecular probes that selectively target QFS have been investigated to delineate their biological role and to identify potential therapeutic agents. Peptide nucleic acids (PNAs) targeting to QFS can be designed using two different approaches. In the first, complementary cytosine-rich PNAs can hybridize to the target QFS by forming PNA:DNA or PNA:RNA hybrid duplexes. In the second, guanine-rich PNAs can hybridize to the homologous DNA or RNA target by forming the corresponding heteroquadruplexes. This review discusses the principles and the recent improvements of the complementary and homologous hybridization modes of PNA oligomers
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