Effects of Protein Binding on DNA G-Quadruplex Structures

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We report here a study of the binding affinity of a triazatruxene based G-quadruplex ligand and three derivatives to G-quadruplex structures and their selectivity with respect to duplex DNA. The parent compound AZATRUX is the best compound of the series, both in terms of affinity and selectivity
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Quadruplex; Oncogenes; Telomeres; Triazatruxene; DNA Binding

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