Template Assembled Synthetic G-Quadruplex: a Novel Biomolecular System for Investigating the Interactions of Ligands with Constrained Quadruplex Conformation
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We report on the design of a new biomolecular device based on the concept of Template Assembled Synthetic G-Quadruplex (TASQ), where quadruplex DNA structures are assembled on a scaffold for constraining G-quadruplex conformation. As a proof of concept, parallel-stranded conformation of G-quadruplex was prepared by using a cyclodecapeptide as the template. As anticipated the use of the scaffold allows the precise control of the conformation of the quadruplex and increases dramatically the stability of the motif. This device was used for investigating by Surface Plasmon Resonance the affinity of ligands for G-quadruplex DNA
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S. Neidle, FEBS J., Human Telomeric G-Quadruplex: The Current Status of Telomeric G-Quadruplexes as Therapeutic Targets in Human Cancer, FEBS J., Volume 277 (Issue 5), March 2010, Pages 1118-1125.
S. Balasubramanian L. H. Hurley S. Neidle, Targeting G-Quadruplexes in Gene Promoters: a Novel Anticancer Strategy, Nat. Rev. Drug Discov., Volume 10 (Issue 4), April 2011, Pages 261-275.
M. Franceschin, G-Quadruplex DNA Structures and Organic Chemistry: More Than One Connection, Eur. J. Org. Chem. (Issue 14), May 2009, Pages 2225-2238.
A. Arola, R. Vilar, Stabilisation of G-Quadruplex DNA by Small Molecules, Curr. Topics Med. Chem., Volume 8 (Issue 15), October 2008, Pages 1405-1415.
D. Monchaud, M.-P. Teulade-Fichou, A Hitchhiker’s Guide to G-Quadruplex Ligands, Org. Biomol. Chem., Volume 6 (Issue 4), 2008, Pages 627-636.
P. Murat, Y. Singh, E. Defrancq, Methods for Investigating G-quadruplex DNA/Ligand Interactions, Chem. Soc. Rev., Volume 40, 2011, in press. DOI: 10.1039/C1CS15117G
J. L. Huppert, Four-Stranded Nucleic Acids: Structure, Function and Targeting of G-Quadruplexes, Chem. Soc. Rev., Volume 37 (Issue 7), 2008, Pages 1375-1384.
P. Murat, D. Cressend, N. Spinelli, A. Van der Heyden, P. Labbé, P. Dumy, E. Defrancq, Novel Conformationally Constrained Parallel G-Quadruplex ChemBioChem, Volume 9 (Issue 16), November 2008, Pages 2588-2591.
P. Murat, R. Bonnet, A. Van der Heyden, N. Spinelli, P. Labbé, D. Monchaud, M.-P. Teulade-Fichou, P. Dumy, E. Defrancq, Template-Assembled Synthetic G-Quadruplex (TASQ): A Useful System for Investigating the Interactions of Ligands with Constrained Quadruplex Topologies, Chem. Eur. J., Volume 16 (Issue 20), May 2010, Pages 6106-6114.
D. Boturyn, E. Defrancq, G. T. Dolphin, J. Garcia, P. Labbe, O. Renaudet, P. Dumy, RAFT Nano-constructs: surfing to biological applications, J. Pept. Sci. Volume14 (Issue 2), February 2008, Pages 224-240.
O. P. Edupuganti, Y. Singh, E. Defrancq, P. Dumy, New Strategy for the Synthesis of 3', 5'-Bifunctionalised Oligonucleotide Conjugates through Sequential Formation of Chemoselective Oxime Bonds, Chem. Eur. J., Volume 10 (Issue 23), December 2004, Pages 5988-5995.
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