Hit Identification of Anthraquinone Based Molecules as c-myc G-Quadruplex Inducers/Stabilizers via in silico Structural Similarity Approach
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Natural products in Traditional Chinese Medicine (TCM) such as anthraquinone derivatives have a wide variety of pharmacological properties as well as proven record of high efficacy. Previously, our group reported an anthraquinone derivative Fonsecin B as c-myc G-quadruplex stabilizer. We herein report two bioactive anthraquinones with modifiable hydroxyl groups abundant in Chinese Medicine Rheum Palmatum L. (also known as Da Huang) as c-myc G-quadruplex stabilizer, identified by in silico structural similarity approach. Interaction of the anthraquinones with c-myc G-quadruplex was investigated by PCR Stop Assay
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Davis, T. L., A. B. Firulli, et al., Crystal structure of parallel quadruplexes from Human telomeric DNA, Nature, Volume 417, (Number 6891), June 2002, Pages 876-880.
Dexheimer, T. S., D. Sun, et al., Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter, Journal of the American Chemical Society, Volume 128, (Issue 16), March 2006, Pages 5404-5415.
Fernando, H., A. P. Reszka, et al., A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene, Biochemistry, Volume 45, (Issue 25), June 2006, Pages 7854-7860.
Rangan, A., O. Y. Fedoroff, et al., Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule, Journal of Biological Chemistry, Volume 276, (Issue 7), February 2001, Pages 4640-4646.
Rankin, S., A. P. Reszka, et al., Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4 DNA recognized by nuclear proteins, Nucleic Acid Research, Volume 36, (Issue 11), May 2008, Pages 3765-3780.
Sen, D. and W. Gilbert, et al., Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis, Nature, Volume 334, (Issue 6180), July 1988, Pages 364-366.
Ambrus, A., Chen, D., et al., Solution Structure of the Biologically Relevant G-Quadruplex Element in theHuman c-myc Promoter. Implications for G-Quadruplex Stabilization, Biochemistry, Volume 44, (Issue 6), February 2005, Pages 2048-2058.
Davis, T. L., A. B. Firulli, et al., Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene, Proceedings of the National Academy of Sciences, Volume 86, (Issue 24), December 1989, Pages 9682-9686 .
 Balasubramanian, S., L. H. Hurley, et al., Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?, Nature Reviews Drug Discovery, Volume 10, (Issue 4), April 2011, Pages 261-275
Campbell, N. H., G. N. Parkinson, et al., Structural Basis of DNA Quadruplex Recognition by an Acridine Drug, Journal of the American Chemical Society, Volume 130, (Issue 21), May 2008, Pages 6722-6724.
Caprio, V., B. Guyen, et al., A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline, Bioorganic & Medicinal Chemistry Letters, Volume 10, (Issue 18), September 2000, Pages 2063-2066.
J. Seenisamy, S. Bashyam, et al., Design and synthesis of an expanded porphyrin that has selectivity for the c-myc G-quadruplex structure, Journal of the American Chemical Society, Volume 127, (Issue 9), March 2005, Pages 2944-2959.
Lee, H. M., D. S. H. Chan, et al., Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening, Chemical Communications, Volume 46, (Issue 26), July 2010, Pages 4680-4682.
Bleicher, K. H. et al., Hit and lead generation: beyond high-throughput Screening, Nature Reviews Drug Discovery, Volume 2, (Issue 5), May 2003, Pages 369-378 .
Harvey, A. L. et al., Natural products in drug discovery, Drug Discovery Today, Volume 13, (Issue 19-20), October 2008, Pages 894-901.
I.M. Kapetanovic, Computer-aided drug discovery and development (CADDD): In silico-chemico-biological approach, Chemico-Biological Interactions, Volume 171, (Issue 2), January 2008, Pages 165-176.
Maxim Totrov, Atomic Property Fields: Generalized 3D Pharmacophoric Potential for Automated Ligand Superposition, Pharmacophore Elucidation and 3D QSAR, Chemical Biology & Drug Design, Volume 71, (Issue 1), January 2008, Pages 15-27.
Atomic Property Field (APF) is a multi-component 3D pharacophoric potential and is commonly utilized in drug discovery. It consists of seven physical and chemical components (hydrogen bond donors, acceptors, Sp2 hybridization, lipophilicity, size, electropositive/negative and charge). Herein the APF potential of each natural product is generated from a template, Fonsecin B and is then globally optimized with the internal force-field energy of the natural product.
Steven Foster, Chongxi Yue, Herbal Emissaries, Bringing Chinese Herbs to the West: A Guide to Gardening, Herbal Wisdom, and Well-Being (Healing Arts Press, 1992, pp. 134-145).
Kang, S. C., Lee, C. M. et al., Anti-Proliferative Effects of Estrogen Receptor-Modulating Compounds Isolated from Rheum palmatum, Archives of Pharmacal Research, Volume 31(number 6), June 2008, Pages 722-726.
Kang, S. C., Lee, C. M. et al., Evaluation of Oriental Medicinal Herbs for Estrogenic and Antiproliferative Activities, Phytotherapy Research, Volume 20, (Issue 11), Pages 1017-1019.
Shi, P., Huang, Z., Chen, G., Rhein Induces Apoptosis and Cell Cycle Arrest in Human Hepatocellular Carcinoma BEL-7402 Cells, The American Journal of Chinese Medicine, Volume 36, (Issue 4), August 2008, Pages 805-13.
Liu, X. Q., Y. Jin, et al., Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA, Analytical Methods, Volume 3, (Issue 6), June 2011, Pages 1270-1273.
Siddiqui-Jain, A., C. L. Grand, et al., Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-myc transcription, Proceedings of the National Academy of Sciences, Volume 99, (Issue 18), September 2002, Pages 11593-11598.
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