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Purine Nucleoside Phosphorylase as a Molecular Target to Develop Active Compounds Against Mycobacterium Tuberculosis
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DOI: https://doi.org/10.15866/irebic.v1i1.1490
Abstract
Despite the availability of chemotherapic and prophylactic approaches to fight consumption, human tuberculosis (TB) continues to claim millions of lives annually, mostly in developing nations, generally due to limited resources available to ensure proper treatment and where human immunodeficiency virus infections are common. Moreover, rising drug-resistant cases have worsened even further this picture. Accordingly, new therapeutic approaches have become necessary. The use of defined molecular targets could be explored as an attempt to develop new and selective chemical compounds to be employed in the treatment of TB. The present review highlights purine nucleoside phosphorylase, a component enzyme of the purine salvage pathway, as an attractive target for the development of new antimycobacterial agents, since this enzyme has been numbered among targets for Mycobacterium tuberculosis persistence in the human host. Enzyme kinetics and structural data are discussed to provide a basis to guide the rational anti-TB drug design.
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