Poly (Methyl Methacrylate-co-Maleic Anhydride-co-N-Isopropylacrylamide): Synthesis, Characterization and Antimicrobial Activity
the author of the article can submit here a request for assignment of a DOI number to this resource!
Cost of the service: euros 10,00 (for a DOI)
In this study, terpolymers of methyl methacrylate (MMA), maleic anhydride (MA) and N-isopropyl acrylamide (NIPA) were synthesized with different reaction times using 1,4-dioxane as a solvent and 2,2-Azobisisobutyronitrile (AIBN) as initiator at 65 °C. Terpolymers of different molecular weight having different reaction times were prepared. By employing various reaction times, MMA-MA-NIPA terpolymers with molecular weights ranging between 49 480 and 60 302 were obtained. The terpolymers were characterized by FTIR and UV-vis spectroscopy, viscosity measurement, solubility testing. Terpolymer composition was determined with 1H NMR spectroscopy and elemental analysis. Thermal properties were investigated by using TGA, DTA and DSC. It was observed that glass transition temperature (Tg) of terpolymers decreased with increasing of MMA and MA contents in terpolymers. The molecular weight and polydispersity index were determined by gel permeation chromatography (GPC). These anhydride-containing polymers differ significantly from other water-soluble polymer systems because their solution process is accompanied by spontaneous hydrolysis of anhydride linkages with the formation of strong hydrogen-bonded carboxylic fragments in the side chains of the macromolecules. The terpolymers were tested for their antimicrobial properties against selected pathogen bacteria and it was observed that depending on the carboxylic, methacrylate and acrylamide content of the polymers the antimicrobial activities differ
Copyright © 2010 Praise Worthy Prize - All rights reserved.
D. Spridon, L. Panaitescu, et al., Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride-Vinyl Acetate, Maleic Anhydride-Methyl Methacrylate and Maleic Anhydride-Styrene, Polymer International, Volume 43, (Issue 2), June 1997, Pages 175-181.
S. Ranganathan, W.E. Baker, et al., Peroxide Initiated Maleic Anhydride Grafting: Structural Studies On An Ester-containing Copolymer and Related Substrates, Journal of Polymer Science Part A: Polymer Chemistry, Volume 37, (Issue 11), June 1999, Pages 1609-1618.
G.B. Butter, Anionic Polymer Drugs (Wiley-1980).
Z.M.O. Rzaev, Complex-Radical Alternating Copolymerization, Progress in Polymer Science, Volume 25, (Issue 2), March 2000, Pages 163-217.
L. Veron, M.C.D. Bignicourt, et al., Syntheses of Poly[N-(2,2 Dimethoxyethyl)-N-methyl acrylamide] for The Immobilization of Oligonucleotides, Journal of Applied Polymer Science, Volume 60, (Issue 11), April 1996, Pages 235-244.
C. Ladaviere, A. Domard, et al., Covalent Immobilization of Biological Molecules to Maleic Anhydride and Methyl Vinyl Ether Copolymers - A Physico-Chemical Approach, Journal of Applied Polymer Science, Volume 71, (Issue 6), February 1999, Pages 927-936.
C. Chaix, C. Minard-Basquin, et al., Oligonucleotide Synthesis on Maleic Anhydride Copolymers Covalently Bound to Silica Spherical Support and Characterization of The Obtained Conjugates, Journal of Applied Polymer Science, Volume 70, (Issue 12), December 1998, Pages 2487-2497.
G.B. Buttler, Cyclopolymerization and Cyclocopolymerization (Marcel Dekker-1992).
S.W. Shabaly, A.S. Hoffman, et al., Polymers as Biomaterials (Plenum Press-1984).
M. Ignatova, N. Manolova, et al., Water-Soluble Polymers Bearing Biologically Active Residues, 3. Hydrolysis of Polyethers and Poly(ether-ester)s Bearing 1-Naphthylacetyl Groups, Macromolecular Chemistry and Physics, Volume 196, (Issue 5, May 1995, Pages 1663-1669.
S. Richardson, P. Ferruti, et al., Poly(amidoamine)s as Potential Endosomolytic Polymers: Evaluation In vitro and Body Distribution in Normal and Tumour-Bearing Animals, Journal of Drug Targeting, Volume 6, (Issue 6), July 1999, Pages 391-404.
R. Duncan, Polymer Conjugates for Tumour Targeting and Intracytoplasmic Delivery. The EPR Effect as A Common Gateway?, Pharmaceutical. Science & Technology Today, Volume 2, (Issue 11), Nowember 1999, Pages 441-449.
E. Gianasi, M. Wasil, et al., HPMA Copolymer Platinates as Novel Antitumour Agents: In vitro Properties, Pharmacokinetics and Antitumour Activity In vivo, European Journal Cancer, Volume 35, (Issue 6), June 1999, Pages 994-1002.
J.S. Patel, S.V. Patel, Bioactive Polymers: Synthesis, Release Study and Antimicrobial Properties of Polymer Bound Ampicillin, Die Angewandte Makromolekulare Chemie, Volume 271, (Issue 1), Nowember 1999, Pages 24-27.
G. Sun, T. Chen, T., et al., A Novel Biocidal Styrenetriazinedione Polymer, Polymer, Volume 37, (Issue 16), August 1996, Pages 3753-3756.
H.K. Can, A.L. Doğan, et al., Synthesis and Antitumor Activity of Poly(3,4-Dihydro-2H-Pyran-co-Maleic Anhydride-co-Vinyl Acetate), Journal of Applied Polymer Science, Volume 96, (Issue 6), June 2005, Pages 2352-2359.
A.D. Ernest, D.W. Lamb, Observation of Axial Acoustic Waves in Multimode PMMA Optical Fibres and Implications for A New Class of Optical Fibre Sensor, Journal of Physics: Conference Series, Volume 15, September 2005, Pages 270-275.
E. Vargün, M. Sankir, et al., Synthesis and Characterization of 2-Hydroxyethyl Methacrylate (HEMA) and Methyl Methacrylate (MMA) Copolymer Used as Biomaterial, Journal of Macromolecular Science Part A: Pure and Applied Chemistry, Volume 47, (Issue 3), March 2010, Pages 235-240.
T. Susdorf, D. del Agua, et al., Photophysical Characterization of Pyrromethene 597 Laser Dye in Silicon-Containing Organic Matrices, Applied Physics B, Volume 86, (Issue 3), February 2007, Pages 537-545.
K.M. Abedin, M. Alvarez, et al., 10 kHz Repetition Rate Solid-State Dye Laser Pumped by Diode-pumped Solid-State Laser, Optics Communications, Volume 218, (Issue 4-6), April 2003, Pages 359-363.
M. Atai, D.C. Watts, et al., Shrinkage Strain-Rates of Dental Resin-Monomer and Composite Systems, Biomaterials, Volume 26, (Issue 24), August 2005, Pages 5015-5020.
M. Arimoto, H. Ichikawa, et al., Microencapsulation of Water-Soluble Macromolecules with Acrylic Terpolymers by The Wurster Coating Process for Colon-Specific Drug Delivery, Powder Technology, Volume 141, (Issue 3), March 2004, Pages 177-186.
M. Talu, E. Uzluk, et al., Synthesis and Characterization of Antimicrobial Copolymer and Terpolymers, Drugs of the Future, Volume 32, (Issue Suppl. A), July 2007, Pages 99-100.
N. Raman, A. Kulandaisamy, et al., Synthesis, Spectral, Redox and Antimicrobial Activities of Schiff Base Complexes Derived From 1-Phenyl-2,3-Dimethyl-4-Aminopyrazol-5-one and Acetoacetanilide, Transition Metal Chemistry, Volume 26, (Issue 1-2), February 2001, Pages 131-135.
S. Dinçer, V. Köseli, Radical Copolymerization of N-Isopropylacrylamide with Anhydrides of Maleic and Citraconic Acids, European Polymer Journal, Volume 38, (Issue 11), Nowember 2002, Pages 2143-2151.
N.R. Cameron, J.M.G. Ferguson, et al., Enthalpy Relaxation of Styrene–Maleic Anhydride (SMA) Copolymers Part 1. Single Component Systems, Polymer, Volume 41, (Issue 19), September 2000, Pages 7255-7262.
U. Eisele, Introduction to Polymer Pyhsics (Springer-1990).
A. Temiz, S.O. Togay, et al., Antimicrobial Poly(N-Vinyl-2-Pyrrolidone-alt-Maleic Anhydride)/Poly(Ethylene Imine) Macrocomplexes, Journal of Applied Polymer Science, Volume 102, (Issue 6), December 2006, Pages 5841-5847.
B.L. Rivas, E.D. Pereira, et al., Water-Soluble Cationic Polymers and Their Polymer-Metal Complexes With Biocidal Activity: A Genotoxicity Study, Journal of Applied Polymer Science, Volume 87, (Issue 3), January 2003, Pages 452-457.
H.K. Can, A.L. Doğan, et al., Synthesis, Characterization, and Antitumor Activity of Poly(Maleic Anhydride-co-Vinyl Acetate-co-Acrylic Acid), Journal of Applied Polymer Science, Volume 100, (Issue 5), June 2006, Pages -34253432.
- There are currently no refbacks.
Please send any question about this web site to email@example.com
Copyright © 2005-2020 Praise Worthy Prize