Effect of Piperine on Lipid Profile of Non-Transgenic Mice
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Background: Piperine was isolated from Piper nigrum popularly known as black pepper. There were many studies earlier about piperine that it is powerful bio-enhancer for many drugs especially antibiotics. Piperine extract is believed to potentiate drugs several folds. The present study was focused on its effect individually on biochemical parameters like blood sugar and lipid profile before and after the administration of piperine. Materials and methods: 30 non-transgenic mice, obtained from the animal house of faculty of Medicine, Garyounis University, Benghazi, Libya were utilized for this study. These mice were fed with high cholesterol diet and were divided into 2 groups. 20 mice were administered Piperine with a dose of 5mg/kg body weight (Group I). Piperine was isolated in Department of Pharmacognosy, Faculty of Pharmacy, Garyounis University, Benghazi.10 mice were not administered piperine, but given high fat diet (Group II). These mice were anaesthetized with ketamine and halothane and blood was withdrawn from each mouse before study by cardiocentesis. Piperine was administered with high fat diet for 3 weeks for group I mice and only high fat diet given to mice belonging to group II. Blood samples were drawn again after 3 weeks from both the groups. Blood sugar, Serum, Cholesterol, Serum triglycerides and Serum high density lipoprotein (HDL) cholesterol were measured in the Serum using authenticated methods. Results: Blood sugar was significantly elevated (p=0.001) after 3 weeks of administration of the piperine whereas it was decreased in groupB who were not given piperine. Serum cholesterol was significantly elevated (p=0.0025) after 3 weeks administration of piperine with high fat diet. There was no decrease in the cholesterol levels after piperine administration, when compared with that of groupB where the piperine was not administered. Serum triglycerides levels were significantly decreased (p=0.0005) after the administration of piperine but there was no significant difference in other group. HDL cholesterol was significantly elevated (p=0.0032) after administration of piperine and it was not significant (p=0.6553) in the group where no piperine was administered. Conclusion: According to this study, the beneficial effect of piperine appears to be in lowering triglycerides and increasing HDL cholesterol. Further research may show promising results on HDL rise. This study does not shown the role of piperine in reducing blood sugar and total cholesterol
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K Srinivasan. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Critical Reviews in Food Science and Nutrition, Volume 47 (Issue 1), 2007, Pages 735-748.
L Michael, Bishop, et al. Clinical Chemistry. Principles, Procedures, Correlations, 3rd edition. 1996: 313-314, 317, 318.
CL Allain, LS Poon, et al. Enzymatic determination of total serum cholesterol, Clinical Chemistry, Volume 20, 1974, Pages 470-475.
M Werner, DG Garberielson, et al. Ultramicro determination of serum triacylglycerols by bioluminescent assay, Clinical Chemistry, Volume 27, 1981, Pages 268-271.
Fluitest LDL-CHOL Kit method: HDL-cholesterol precipitation for enzymatic assay for the direct quantitative determination of HDL-cholesterol. Biocon Diagnostic Inc Hecke 8-34516 Vohl/Mariehagen Germany.
Fluitest HDL-CHOL Kit method: LDL-cholesterol precipitation for enzymatic essay for quantitative determination of LDL-cholesterol. Biocon Diagnostic Inc Hecke 8-34516 Vohl/Mariehagen Germany.
RS Vijayakumar, N Nalini. Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats, Journal of Basic Clinical Physiology and Pharmacology, Volume 17 (Issue 2), 2006, Pages 71-86.
RS Vijayakumar, D Surya, et al. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress, Redox Report: Communications in Free Radical Research, Volume 9 (Issue 2), 2004, Pages 105-110.
RS Vijayakumar, N Nalini. Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats, Cell Biochemistry and Function, Volume 24 (Issue 6), 2006, Pages 491-498.
UH Park, HS Jeong, et al. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells, Journal of Agricultural and Food Chemistry, Volume 60 (Issue 15), April 2012, Pages 3853-3860.
G Kaur, C Meena. Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of "curcumin with piperine and quercetin", ISRN Pharmacology, 2012;2012:957283. Epub 2012 Mar 8.
G Luvarà, ME Pueyo, et al. Chronic blockade of NO synthase activity induces a proinflammatory phenotype in the arterial wall: prevention by angiotensin II antagonism, Arteriosclerosis Thrombosis and Vascular Biology, Volume 18, 1998, Pages 1408–1416.
SI Taqvi, AJ Shah, et al. Blood pressure lowering and vasomodulator effects of piperine. Journal of Cardiovascular Pharmacology, Volume 52, 2008, Pages 452–458.
L Hlavačková, A Janegová, et al. Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension, Nutrition and Metabolism (London), Volume 8, 2011, Page 72.
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