Nonlinear Modeling and Estimation Techniques for a Fed-Batch Prototype Bioprocess


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Abstract


This paper presents nonlinear modeling and estimation techniques dedicated to a fed-batch prototype bioprocess. More precisely, this prototype bioprocess is an aerobic microbial growth process coupled with an enzyme-catalyzed reaction, which is widely used in bioindustry. As a modeling procedure, the present work proposes an innovative methodology, namely the bond graph approach. In order to obtain a useful model for control purposes, it is necessary to derive estimation strategies for unmeasurable states and kinetic parameters. By using some model structural properties, an asymptotic state observer is derived. Also, the nonlinear and uncertain kinetic rates of this process are on-line estimated by using a high-gain observer. The performance and behavior of estimation techniques are analyzed via numerical simulations.
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Keywords


Nonlinear Systems; Modeling; Bond Graphs; Estimation; Biotechnology

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References


D. Dochain, P. Vanrolleghem, Dynamical Modelling and Estimation in Wastewater Treatment Processes (IWA, 2001).

K. Schugerl, Progress in monitoring, modelling and control of bioprocesses during the last 20 years, Journal of Biotechnology, Vol. 85(No. 2):149-173, 2001.

D. Dochain (Ed.), Automatic Control of Bioprocesses (ISTE Publ. and Wiley & Sons, 2008).

G. Bastin, D. Dochain, On-line Estimation and Adaptive Control of Bioreactors (Elsevier, 1990).

M. Roman, D. Selişteanu, Modeling issues and structural properties of a class of nonlinear bioprocesses, Int. Review of Automatic Control, Vol. 3(No. 6):578-587, November 2010.

D. Karnopp, R. Rosenberg, System Dynamics: A Unified Approach (John Wiley, 1974).

J. Thoma, Introduction to Bond Graphs and their Applications (Pergamon Press, 1975).

G. Dauphin-Tanguy (Ed.), Les Bond Graphs (Hermes Sci., 2000).

J. Thoma, B. Ould Bouamama, Modelling and Simulation in Thermal and Chemical Engineering. A Bond Graph Approach (Springer, 2000).

M. Roman, E. Bobaşu, D. Selişteanu, and D. Şendrescu, Bond Graph modelling of chemical reaction based processes, (2010) International Review on Modelling and Simulations (IREMOS), 3 (1), pp. 108-115.

D.A. Linkens, Bond graphs for an improved modelling environment in the lifesciences, IEE Colloquium on Bond Graphs in Control, pp. 3/1-3/4, London, UK, 1990.

D. Selişteanu, M. Roman, and D. Şendrescu, Pseudo bond graph modelling and on-line estimation of unknown kinetics for a wastewater biodegradation process, Simulation Modelling Practice and Theory, Vol. 18(No. 9):1297-1313, 2010.

M. Roman, Modelling aspects and structural properties of a fed-batch bioprocess, Lecture Notes in Computer Science (EUROCAST), Vol. 6927(Part I):105-112, 2012.

S. Kamoun, M. Kamoun, A new parametric estimation algorithm for large-scale systems described by state-space mathematical models, (2009) International Review of Automatic Control (IREACO), 2 (1), pp. 17-26.

H.K. Khalil, High-gain observers in nonlinear feedback control, Int. Conference on Control, Automation & Systems ICCAS 2008, pp. xlvii-lvii, Seoul, Korea, 2008.

M. Farza, K. Busawon, and H. Hammouri, Simple nonlinear observers for on-line estimation of kinetic rates in bioreactors, Automatica, Vol. 34(No. 3):301-318, 1998.

J.P. Gauthier, H. Hammouri, and S. Othman, A simple observer for nonlinear systems. Applications to bioreactors, IEEE Trans. in Automatic Control, Vol. 37(No. 6):875-880, 1992.

D. Selişteanu, Modeling and Control of Bioreactors (in Romanian) (Universitaria Publ., 2001).

D. Selişteanu, C. Marin, E. Petre, and D. Şendrescu, Nonlinear observers for the estimation of kinetic parameters in an alcoholic fermentation bioprocess, (2011) International Review of Automatic Control (IREACO), 4 (1), pp. 124-132.


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