Effect of Soy Protein Supplementation on Hepatic Lipid Profile in Rats Fed a Cholesterol-Based Diet

Olarewaju M. Oluba; Fisayo A. Bamisaye; Augustine O. Olusola; Anthony O. Iyamu; George O. Eidangbe

doi:10.15866/irebic.v2i5.1538

Effect of Soy Protein Supplementation on Hepatic Lipid Profile in Rats Fed a Cholesterol-Based Diet

Olarewaju M. Oluba^(1*), Fisayo A. Bamisaye⁽²⁾, Augustine O. Olusola⁽³⁾, Anthony O. Iyamu⁽⁴⁾, George O. Eidangbe⁽⁵⁾

^(*) Corresponding author

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Abstract

The effect of soy protein intake on liver lipid homeostasis in cholesterol-fed rats was investigated. One hundred and five albino Wistar rats divided into five groups (n = 21) were fed 20% soy protein without cholesterol (A), 20% soy protein + 5% cholesterol (B), 20% soy protein + 10% cholesterol (C), 0% soy protein + 20% cholesterol (D), and 5% soy protein + 20% cholesterol (E) for six weeks. Liver total cholesterol, esterified cholesterol, low density lipoprotein cholesterol and triglyceride levels were significantly reduced (p<0.05) in soy protein fed rats (B and C) when compared with those fed cholesterol with no or minimal soy protein (D and E) supplement respectively. It could thus be concluded that soy protein supplementation reduces hepatic lipid load in hypercholesterolemic rats
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Keywords

Soy Protein; Liver Lipids; Cholesterol; Hypercholesterolemia

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References

W.B. Kannel, J.T Doyle, CD Ostfeld, L. Kuller, R.N. Podell, J. Stamler, Optimal resources for the primary prevention of atheroslerorotic diseases, Circulation 1984, 70, pp. 157A-205A.

M.J. Richard, D.C. Serbus, D.C. Beitz, N.L. Jacobson, Effect of type and amount of dietary fat on concentration of cholesterol in blood plasma and tissues of rabbits, Nutrition Research 1982, pp. 2, 175-183.

D.K. Spady, J.M. Dietschy, Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster, Proceeding of National Academy of Science USA 1985, 82, pp. 4526-4530.

T. Toda, Y. Toda, V.K. Yamamoto, F.A. Kummerow, Comparative study on the atherogenicity of dietary trans saturated and unsaturated fatty acids on swin coronary arteries, Journal of Nutrition Science and Vitaminology 1985, 31, pp. 233-241.

D.M. Hegsted, R.B. Mcgandy, M.L. Myers, J.F. Stare, Quantitative effects of dietary fats on serum cholesterol in man, American Journal of Clinical Nutrition 1965, 17, pp. 281-295.

K.K. Carroll. Hypercholesterolemia and effects of dietary protein, Fed Proceeding 1982, 41, pp. 2792-2796.

K. Widhalm, G. Brazda, B. Schneider, S. Kohl, Effects of soy protein diet versus standard low fat, low cholesterol diet on lipid and lipoprotein levels in children with familial or polygenic hypercholesterolemia, Journal of Pediatry 1993, 123, pp. 30-34.

H. Meinertz, K. Nilausen, O. Fergeman, Effect of dietary protein on plasma lipoprotein levels in normal subjects: Interaction with dietary cholesterol, Journal of Nutrition Science and Vitaminology 1990, 36, pp. S157- S164.

H.J. Teede, F.S. Dalais, D. Kotsopoulos, Y.L. Liang, S. Davis, B.P. McGrath, Dietary soy has both beneficial and potentially adverse cardiovascular effect: a placebo-controlled study in men and postmenopausal women, Journal of Clinical Endocrinology & Metabolism 2001, 86, pp. 3053- 3060.

A. Eklund, L. Sjoblom, Effect of dietary proteins on hepatic and plasma lipids, and some properties of major plasma lipoprotein fractions during dietary-induced hypercholesterolemia in male rats, Biochimical & Biophysical Acta 1986, 877, 127-134.

K.D. Wiggers, K.K. Miller, M.J. Richard, J.W. Stewart, N.L. Jacobson, Effects of beef- and soy-based diets on cholesterol disposition in swine, Fed Proceeding 1980, 39, Page 366 (abs).

L.S. Walsh, K.D. Wigger, M.J. Richard, N.L. Jacobson, Effects of soy versus beef diets on blood and tissue cholesterol and body composition of growing swine, Nutrition Research 1983, 3, pp. 557- 569.

D.A. Diersen-Schade, M.J. Richard, D.C. Beitz, N.L. Jacobson. Plasma, tissue and fecal cholesterol of growing pigs fed restricted or liberal amounts of beef, soy or conventional diets, Journal of Nutrition 1986, 116, pp. 2086- 2095.

J.M. Dietschy, Regulation of cholesterol metabolism in man and other species, Klin Wochenschr 1984, 62, pp. 338-345.

S. Stender, D.B. Zilversmit, In vivo influx, tissue esterification and hydrolysis of free and esterified plasma cholesterol in cholesterol-fed rabbit, Biochimical & Biophysical Acta 1981, 663, pp. 674-686.

E.C. Onyeneke, E.O. Alumanah, I.C. Ononogbu,. Changes in plasma lecithin: cholesterol acyltransferase activity in rats fed a cholesterol diet, Journal of Clinical Biochemistry & Nutrition 1990, 10, pp. 27-37.

National Research Council, Guides for the Care and Use of Laboratory Animals, National Institutes of Health, Bethesda, MD 1985.

J. Folch, M. Lees, G.H. Sloane-Stanley, A simple method for the isolation and purification of total lipids from animal tissues, Journal of Biology & Chemistry 1957, 226, pp. 497-509.

R.L. Searcy, L.M. Bergquist, A new colour reaction for the quantitation of serum cholesterol, Clinical Chimical Acta 1960, 5, pp. 192-199.

N.W. Tiez, Clinical Guide to Laboratory Tests. 2nd Edn, WB Saunders Company, Philadelphia, USA, pp. 554-554.

W.T. Friedewald, R.I. Levy, D.S. Fredrickson, Estimation of the concentration of low density lipoprotein in plasma, without use of the preparative ultracentrifuge, Clinical Chemistry 1972, 18, pp. 499-502.

F. Basso, L. Freeman, C.L. Knapper, A. Ramaley, J. Stonik, E.B. Neufeld, T. Tansey, M.J. Amar, J. Frachart-Najib, N. Duverger, Role of the hepatic ABCA 1 transporter in modulating intrahepatic cholesterol and plasma HDL-cholesterol concentration, Journal of Lipid Research 2003, 44, pp. 296-302.

N. Torres, I. Torre-Villalvazo, A.R. Tovar, Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders, Journal of Nutrition Biochemistry 2006, 17(6), pp. 365-373.

C. Ascencio, N. Torres, F. Isoard- Acosta, F.J. Gomez-Perez, R. Hernandez-Pando, A.R. Tovar, Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats, Journal of Nutrition 2004, 134, pp. 522-529.

C.R. Sirtori, A. Gotti, O. Mantero, F. Conti, E. Agradi, L. Tremoli, D. Kritchevsky, Clinical experience in soybean protein diet in the treatment of hypercholesterolemia. American Journal of Clinical Nutrition 1979, 32, pp. 1645-1658.

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