Benzohydroxamic Acid and its Applications: a Review

Richa Arora(1*), Rita Kakkar(2)

(1) University of Delhi, India
(2) University of Delhi, India
(*) Corresponding author


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Abstract


Hydroxamic acids, R-CO-NH-OH, are a group of naturally occurring and synthetic weak organic acids, having numerous applications in such diverse fields as analytical chemistry, agriculture, pest control, nuclear fuel processing, and corrosion inhibition. Hydroxamic acids are studied as inhibitors of enzymes, e.g., peroxidases, urease and as siderophores for Fe(III) in microbes. Several hydroxamic acids have been studied, of which benzohydroxamic acid (R = C6H5) has emerged as a potent metal chelator and an efficient enzyme inhibitor. This review focuses on benzohydroxamic acid (BHA) and its derivatives and their applications as potent metal chelators and also as inhibitors of various biologically important enzymes like ribonucleotide reductase, urease and matrix metalloproteinase, to name a few
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Keywords


Benzohydroxamic Acid; Chelator; Matrix Metalloproteinase; Ribonucleotide Reductase; Urease

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Authors’ information

Rita Kakkar holds a PhD degree in chemistry from the University of Delhi, which she earned in 1982 for her research on the mechanism of the hydroboration reaction. She has been teaching Physical Chemistry in the University of Delhi for the past three decades. Her major field of research is Computational Chemistry. She has over 75 research publications in reputed international journals in this field. Her research interests include investigation of mechanisms of chemical reactions, including tautomerism, enzyme reactions, and reactions on nanosurfaces.

Prof. Rita Kakkar has successfully supervised the work of 27 PhD and 7 MPhil students. She has delivered several invited talks at scientific conferences. She acted as an International Advisory Member, First-Seventh Workshops on Computational Chemistry and its Applications, part of the International Conference on Computational Science, ICCS: 2006-2012. She regularly reviews manuscripts for many international journals, including those published by the American Chemical Society, Royal Society of Chemistry and Elsevier. Her biography appears in Marquis Who’s Who.

Richa Arora (born 10 July, 1988) is presently pursuing PhD in the Department of Chemistry, University of Delhi, after clearing the CSIR National Eligibility Test. Her research interests include computational modeling, and she has presented her work related to the computational study of benzohydroxamic acid at various conferences.


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